Antinociceptive and anti-inflammatory effects of Nypa fruticans wurmb by suppressing TRPV1 in the sciatic neuropathies

Abstract

Neuropathic pain is generally characterized by sensory abnormalities such as sensory disorders hyperalgesia allodynia. Recent studies have reported that TRPV1 activation is essential for establishing of inflammation in the neuropathy pain models showing that the expression of this receptor is increased contributing to enhanced thermal sensitivity. Nypa fruticans Wurmb (NF) which was used as a folk remedy is a plant that is gaining attention due to its various effects. In this study we investigated the antinociceptive anti-inflammatory effects of NFE (Nypa fruticans Wurmb extracts) by controlling the neurological function of TRPV1. In sciatic crush injury rat models a significant level of antinociceptive effect was observed in the thermal hyperalgesia test in which NF extracts (NFE 500 mg/kg) were orally administered daily. Protein quantification of the sciatic nerve the of the L4–L6 spinal cord showed a decrease of the TRPV1 expression the inflammatory expression factor COX2 proinflammatory factors in the NFE treated groups. Our results indicate that NFE affects antinociceptive and anti-inflammatory by controlling TRPV1 in sciatic neuropathic pain models.