Protocol for a systematic review and meta‐analysis of experimental models of amyotrophic lateral sclerosis

Abstract

Amyotrophic lateral sclerosis ( ALS ) is a rapidly progressive neurodegenerative disease with no cure and limited treatment options. There is therefore an urgent need for effective therapeutic interventions in this disease. This protocol outlines the strategy for a systematic review and meta‐analysis to identify, from in vivo animal and human induced pluripotent stem cell ( hiPSC ) studies, potential therapeutic interventions for ALS . Our aim is to perform a comprehensive review of the ALS literature to compile a list of (1) candidate interventions and (2) target pathways that may be of therapeutic benefit in patients with ALS .