The hypoxic transcription factor Kl Mga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis

12Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Hypoxia is defined as the decline of oxygen availability, depending on environmental supply and cellular consumption rate. The decrease in O2 results in reduction of available energy in facultative aerobes. The response and/or adaptation to hypoxia and other changing environmental conditions can influence the properties and functions of membranes by modifying lipid composition. In the yeast Kluyveromyces lactis, the KlMga2 gene is a hypoxic regulatory factor for lipid biosynthesis-fatty acids and sterols- A nd is also involved in glucose signaling, glucose catabolism and is generally important for cellular fitness. In this work we show that, in addition to the above defects, the absence of the KlMGA2 gene caused increased resistance to oxidative stress and extended lifespan of the yeast, associated with increased expression levels of catalase and SOD genes. We propose that KlMga2 might also act as a mediator of the oxidative stress response/adaptation, thus revealing connections among hypoxia, glucose signaling, fatty acid biosynthesis and ROS metabolism in K. lactis.

Cite

CITATION STYLE

APA

Santomartino, R., Camponeschi, I., Polo, G., Immesi, A., Rinaldi, T., Mazzoni, C., … Bianchi, M. M. (2019). The hypoxic transcription factor Kl Mga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis. FEMS Yeast Research, 19(3). https://doi.org/10.1093/femsyr/foz020

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free