Can neuroprotection effectively manage primary open-angle glaucoma? a protocol of systematic review and meta-analysis

Abstract

Background:This study aims to assess the efficacy of neuroprotection (NP) for the management of patients with primary open-angle glaucoma (POAG).Methods:A comprehensive search will be carried out from the beginning to the February 29, 2020 in the electronic databases: Scopus, Web of Science, PUBMED, EMBASE, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, WANGFANG, and China National Knowledge Infrastructure. There are no limitations related to the language and publication date. Two researchers will independently undertake study selection from searched literatures, extract data from included trials, and appraise study quality using Cochrane risk of bias tool. Any disagreements will be solved by a third researcher through consultation. RevMan 5.3 software will be employed for statistical analysis.Results:This study will provide a high-quality synthesis of randomized controlled trials of NP for the management of patients with POAG.Conclusions:The results of this study will help to create proposals for the treatment of POAG using NP.Systematic review registration:INPLASY202040107.