Lack of association between ACE insertion/deletion polymorphism and lung cancer: A meta-analysis

Abstract

Objective: Previous case-control studies on the relation between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and lung cancer were controversial. In this study, we aimed to further evaluate the relation between the ACE gene I/D polymorphism and lung cancer. Methods: We selected eight case-control studies related to the ACE gene I/D polymorphism and lung cancer by searching PubMed, EMBase, Chinese Biomedical Literature Database, and Wanfang database. We utilized Q-test and I2 test to test the heterogeneity between each study. To merge the odds ratio (OR) and 95% confidence interval, we utilized the fixed-effects model during the analyses. Results: The present study included 1612 patients with lung cancer and 1442 cancer-free control subjects. By metaanalysis, we did not find any association between the ACE gene I/D polymorphism and lung cancer in either genotype or allele distribution (DD vs. (ID+II): OR = 0.96, 95% CI (0.80-1.14), p = 0. 61; D allele vs. I allele: OR = 1.01, 95% CI (0.911.13), p = 0.79). Conclusion: We concluded that the ACE gene I/D polymorphism was not associated with lung cancer.