PPAR gamma activators: Off-target against glioma cell migration and brain invasion

Abstract

Today, there is increasing evidence that PPAR γ agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPAR γ activators mediate their antimigratory and anti-invasive properties remains elusive. This letter gives a short review on the debate and adds to the current knowledge by applying a PPAR γ inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPAR γ independent manner. Copyright © 2008 Sebastian Seufert et al.