Edema disease-like brain lesions in gnotobiotic piglets infected with Escherichia coli serotype O157:H7

Abstract

Gnotobiotic piglets inoculated with Escherichia coli serotype O157:H7 strains that produced Shiga-like toxin II developed brain lesions similar to those observed in edema disease of swine, including arteriolar necrosis and malaria. Loss of ability to produce Shiga-like toxin II resulted in loss of ability to cause brain lesions.