Osteoarticular allograft in surgery for high-grade malignant tumours of bone

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Abstract

We assessed the results of 17 limb-salvage procedures using osteoarticular allografts after wide resection of high-grade malignant bone tumours. All patients received chemotherapy. At the five-year follow-up, three patients had died from metastases. The allografts survived for five years in only seven patients all of whom had good function, ranging from 73% to 90% of normal. The allografts were removed because of fracture in seven patients and infection in one, and in all of these a second limb-salvage procedure was undertaken. With such a low rate of survival of osteoarticular allografts, we believe that their use in the management of high-grade malignant bone tumours should, at best, be considered a temporary solution.

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Rodl, R. W., Ozaki, T., Hoffmann, C., Bottner, F., Lindner, N., & Winkelman, W. (2000). Osteoarticular allograft in surgery for high-grade malignant tumours of bone. Journal of Bone and Joint Surgery - Series B, 82(7), 1006–1010. https://doi.org/10.1302/0301-620X.82B7.10644

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