New prodrug polymers functionalized based on Maleimide

Abstract

In this work, three new drug substituted monomers and new homogenous and heterogeneous polymers were synthesized which loaded with medical properties to extend the controlled drug. The first step includes preparing Maleimic acid (L1) and (L2) via reaction of maleic anhydride with 5-amino salicylic acid. Then compound (L2) was converted to its corresponding acyl chloride derivative which reacted with amino drug (Pseudoephedrine, 4-aminoantipyrine, Paracetamol) afforded (L3-L5) monomers. Homogeneous polymers (L6 and L7) prepared through polymerization reaction of the free radicals of the monomers (L1) and (L2) under nitrogen using (MEKP) as initiator. Heterogeneous polymers (L8 and L9) prepared through polymerization reaction of the free radicals of the monomers (L1), (L2) separately with acrylic acid under nitrogen using (MEKP) as initiator. All these prepared monomer and polymers were characterized by FT-IR and 1H-NMR, 13C-NMR techniques. Controlled drug release and swelling % was studied in different pH values at 37 °C. Intrinsic viscosities were measured at 25 ° C with Ostwald viscometer and applied the characteristic of solubility for these polymers. The physical properties of all prepared monomer and polymers were studied.