Increased hydrolysis of oximino-β-lactams by CMY-107, a Tyr199Cys mutant form of CMY-2 produced by Escherichia coli

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Abstract

The cephalosporinase CMY-107, a Tyr199Cys mutant form of CMY-2 encoded by an IncI self-transferable plasmid carried by an Escherichia coli clinical strain, was characterized. The enzyme hydrolyzed oximino-cephalosporins and aztreonam more efficiently than CMY-2 did.

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Kotsakis, S. D., Miriagou, V., Vetouli, E. E., Bozavoutoglou, E., Lebessi, E., Tzelepi, E., & Tzouvelekis, L. S. (2015). Increased hydrolysis of oximino-β-lactams by CMY-107, a Tyr199Cys mutant form of CMY-2 produced by Escherichia coli. Antimicrobial Agents and Chemotherapy, 59(12), 7894–7898. https://doi.org/10.1128/AAC.01793-15

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