A spontaneous disappeared case of fundic gland polyposis

Abstract

A case of the fundic gland polyposis which disappeared spontaneously was reported. The patient was a 53-year-old female and she was pointed out about 30–40 gastric polyposis distributed at the normal body mucosa by upper GI series roentgenography for mass survey. Because the polyps consisted of fundic glands histopathologically and no atrophy of fundic glands was found in the body mucosa, multiple polyps were diagnosed as fundic gland polyposis. About 10 months later, follow-up roentgenographic and endoscopic examinatios revealed that multiple polyps disappeared almost completely and hypergastrinemia and decrease of acid secretion were also observed. Histopathological findings of the body mucosa showed atrophy and degeneration of fundic glands with marked in-filtraion of round cells, which was clearly different from the histopathological finding of the body at the first examination. Spontaneous disappearance of fundic gland polyposis is very rare and only 6 cases have been reported. The mucosal findings after disappearance of polyps have not been described and the mechanism of disappearance has still unknown. From the observation of the body mucosa after disappearance of polyps, it is suggested that the spontaneous disappearance in this case might be caused by the involvement with atrophic change of the body mucosa. © 1991, Japan Gastroenterological Endoscopy Society. All rights reserved.