Correlation between Leucocyte Count, Neutrophil Lymphocyte Ratio (NLR), C-reactive Protein (CRP) and Coronary Artery Stenosis Degree on Stable Coronary Artery Disease

Abstract

Background: Inflammation plays an important role in stable coronary artery disease (SCAD). Leucocyte count, NLR and CRP are markers of atherogenic and inflammatory processes in the atherosclerosis formation. The stenosis degree indicates a visual evaluation of the percentage reduction of coronary diameter compare with normal coronary artery. Objective: to determine the correlation of leucocyte count, NLR and CRP with the stenosis degree in SCAD. Methods: Analytic-descriptive with cross sectional study in 35 patients with SCAD at Kariadi Hospital. The study was conducted during March-June 2018. Leucocyte count was measured by hematology analyzer. NLR was calculated as the ratio of absolute neutrophil cell count to absolute lymphocyte cell count. CRP was measured by i-chroma reader. Statistical analysis used Spearman test. p<0.05 was significance. Result: Mean±SD leucocyte count, NLR, CRP respectively were 7,54 ± 2,03/µl; 2,10 ± 0,93 and 2,23 ± 1,68 mg/L. Correlation between leucocyte count, NLR, CRP and stenosis degree, respectively were (r= 0,189; p=0,277); (r=0,593; p=0,000); (r=-0,112, p=0,521). Conclusion: There are no significant correlation between leucocyte count and CRP with stenosis degree in SCAD. There is strong positive correlation between NLR and stenosis degree in SCAD that can be used as evaluation marker for high risk patient with SCAD.