Serum miR-146a, miR-155, and miR-210 as potential markers of Graves’ disease

Abstract

Background: Previous studies have demonstrated that dysfunctional regulatory T cells (Tregs) may be associated with Graves’ disease (GD). In this study, we evaluated four serum Treg-associated miRNAs (miR-210, miR-182, miR-155, and miR-146a) expressions and assessed the potential of serum miRNAs as biomarkers of GD. Methods: Foxp3 and serum miRNAs expressions both in GD patients and healthy controls were measured by RT-PCR. Results: Serum miR-210 in GD patients was significantly higher than that of healthy controls (2.64-fold, P