Preparation of Benzimidazole Based Coumarin Derivatives as Antimicrobial and Antioxidant Agents

Abstract

The aim of the present work was to afford benzimidazole-based coumarins as antimicrobial and antioxidant agents. The compounds 3a-3j were prepared by reaction the compounds 1a-1b with the compounds 2a-2e in acetone. Chemical structures of 3a-3j were proven by their spectral analysis. Minimum inhibitory concentrations of 3a-3j were recorded by serial dilution procedure. Antioxidant potential was assessed by the 1,1-diphenyl-2-picrylhydrazyl method. Compounds 1a and 3g were identified as promising antimicrobial agents. Most of the compounds displayed moderate antioxidant activity. It has been concluded that the replacement of the 2-butylthio group with 2-pentylthio or 2-hexylthio substituents and the coumarin structure with another close flavonoid structure may provide better dual antimicrobial/antioxidant compounds.