Antitumor effect of hybrid nanocomplexes containing nanoparticles of orthovanadates rare earth elements and cholesterol

Abstract

An actual task of current oncology is the search for the structures, enabling to selectively affect the tumor stem cells, on the expansion rate of those the activity of oncologic process depends. Perspective in this aspect is the use of nanostructures selectively recognizing and inactivating tumor stem cells. In the research there was studied the effect of synthesized hybrid nanocomplexes based on nanoparticles of rare earth orthovanadates GdYVO4:Eu3+, cholesterol and hydrophobic luminescent stain Dil on functional activity of Ehrlich carcinoma cells and expression in them of nanog, oct-4, sox-2 genes. After pre-Treatment of Ehrlich carcinoma cells with nanocomplexes there was shown an inhibition of tumor growth in vivo due to inactivation of the most carcinogenic CD44hi cells, which was accompanied with the reduced expression rate of the studied genes in total pool of cells. The findings contribute to the understanding of the effect mechanisms of orthovanadates and open the prospects to apple new forms of nanocomposites in treatment of oncology diseases.