Electrochemical oxidation of niclosamide at a glassy carbon electrode and its determination by voltammetry

Abstract

Cyclic voltammetry, square-wave voltammetry and controlled potential electrolysis have been used to study the electrochemical oxidation behaviour of niclosamide at a glassy carbon electrode. The number of electrons transferred, the wave characteristics, the diffusion coefficient and reversibility of the reactions have been investigated. Following optimisation of voltammetric parameters, pH, and reproducibility, a linear calibration curve over the range 1 × 10-6 - 1 × 10-4 mol dm-3 niclosamide was achieved. The detection limit was found to be 8 × 10 -7 mol dm-3. For eight successive determinations of 1 × 10-5 mol dm-3 niclosamide, a relative standard deviation of 3.6% was obtained. This voltammetric method was applied for the determination of niclosamide in tablets.