Human antigen R-mediated mRNA Stabilization is required for ultraviolet b-induced autoinduction of amphiregulin in keratinocytes

Abstract

Background: Amphiregulin (AREG) is a ligand for the EGF receptor (EGFR) and autoinduces its own expression. Results: Human antigen R (HuR), an mRNA-binding protein, stabilizes AREG mRNA in ultraviolet B (UVB)-exposed keratinocytes. Conclusion: HuR is a key regulator for UVB-mediated autoinduction of AREG expression. Significance: Clarifying the mechanisms underlying the production of EGF family members is crucial for understanding cancers caused by aberrant EGFR signaling. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.