Severe Paradoxical Reaction during Treatment of Disseminated Tuberculosis in a Patient with Neutralizing Anti-IFNγ Autoantibodies

Abstract

Interferon-gamma (IFNγ) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFNγ-neutralizing autoantibodies, who developed a severe inflammatory reaction during anti-tuberculosis treatment. IFNγ contributes to host control of tuberculosis but appears inessential for tuberculosis paradoxical reactions. 2015 Published by Oxford University Press for the Infectious Diseases Society of America 2015.