Polyoxypregnane Glycosides from the Roots of Marsdenia tenacissima and Their Anti-HIV Activities

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Abstract

A continuous phytochemical study on the roots of Marsdenia tenacissima led to the isolation and identification of 13 new polyoxypregnane glycosides named marstenacissides B10-B17 (1, 2, 4, 7, 8, 11, 12, and 14) and marstenacissides A8-A12 (3, 9, 10, 13, and 15) in addition to two known polyoxypregnane glycosides marsdenosides M and L (5 and 6). Their structures were established by spectroscopic techniques and by comparison with the reported data in the literature. Moreover, the anti-HIV activities of these isolates and the previous isolated marstenacissides A1-A7 and B1-B9 were assessed, some of which exhibited slight or negligible effects against HIV-1.

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Pang, X., Kang, L. P., Fang, X. M., Zhao, Y., Yu, H. S., Han, L. F., … Ma, B. P. (2017). Polyoxypregnane Glycosides from the Roots of Marsdenia tenacissima and Their Anti-HIV Activities. Planta Medica, 83(1–2), 126–134. https://doi.org/10.1055/s-0042-108057

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