Tandem Mannich/Diels-Alder reactions for the synthesis of indole compound libraries

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Abstract

A tandem Mannich/Diels-Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a,6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within the European Lead Factory (ELF) Consortium.

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Wu, P., Petersen, M. Å., Petersen, R., Flagstad, T., Guilleux, R., Ohsten, M., … Clausen, M. H. (2016). Tandem Mannich/Diels-Alder reactions for the synthesis of indole compound libraries. RSC Advances, 6(52), 46654–46657. https://doi.org/10.1039/c6ra08786h

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