Comparative study of oxidative status and some biochemical parameters in subjects suffered of intermediate and major Thalassemia

Abstract

In the β-thalassemia’s, oxidative stress, resulting from chronic hemolysis, globin chain imbalance, iron overload and depleted antioxidant defenses, likely contributes to cell death, organ damage, anemia, hypoxia and inflammation. Between November 2020 and June 2021, the study assessed adults aged (25-35 years) attending to Hiwa Cancer Hospital/ Sulaimaniah Thalassemia and congenital blood disorders center/ Iraq: 60 patients with HbE β-thalassemia, 30 β-thalassemia major, 30 β-thalassemia intermediate and 30 control subjects. ferritin were measured as sources of oxidants; plasma antioxidants: Glutathione Reductase (GR) and Oxidative stress-induced growth inhibitor 2 (OSGIN2) , plasma D-dimer  assessed thrombosis status and serum C-reactive protein assessed inflammation, the results showed increased in the levels of ferritin,  plasma D-dimer  and CRP in both β-thalassemia major and β-thalassemia intermediate  (2789±789 ; 2657±725.8 ng/ml) , (175.4±54.02; 188.7±62.01 ng/ml) and (15.6±2.6; 13.3±3.1 mg/l) compared to control group (178.7±58.9 ng/ml) , (79.8±34.8 ng/ml) and (2.3± 0.7 mg/l) respectively. Whereas decreased in the levels of GR and OSGIN2 (38.4±12.7; 35±8.8 pg/ml) and (58±18.3; 78±20.5 mg/dl) compared to control group (96±17.3 pg/ml) and (156±65.6 mg/dl ) respectively.