Helicobacter pylori as a risk factor for the development of metabolic syndrome and gallstone disease

Abstract

To study the Helicobacter pylori (H. pylori) effect on gallstone disease development and metabolic syndrome (MetS) and its components, the main factors of biliary stone formation. The study included 143 patients with cholelithiasis, of which 88 (61.5 %) were infected with H. pylori and 55 (38.5 %) were not. All subjects were assessed for MetS and its components` severity. A high prevalence of metabolic disorder and MetS was revealed in patients with H. pylori. The results obtained suggest that H. pylori promotes gallbladder calculi development by affecting patients` metabolic profile.