P07.03 Fluorescence navigation in glioma surgery using 5 ALA and chlorin E6

Abstract

BACKGROUND: Metabolic navigation in the surgery of malignant gliomas is the most effective way to distinguish the border of the tumor during surgery and achieve a more radical resection, and as a result, to increase the recurrence interval and increase the life expectancy. MATERIAL AND METHODS: A comparative analysis of fluorescent navigation was carried out in 50 patients (group 2) with glioma of a high degree of anaplasia, who were treated at the Department of Neurooncology of the A.L. prof. A.L. Polenov. In 25 patients (group 1), chlorin E6 1 mg / kg intravenously was used as a fluorescence inducer, the other 25 patients (group 2) received 5 ALA 20 mg / kg orally. Each group included 10 patients with Grade III anaplasia and 15 patients with Grade IV anaplasia. Both groups were statistically representative (p> 0.05). RESULTS: For surgery of grade III glioma, the sensitivity of the method was 83.3% (chlorin E6), 82.9% (5ALA); specificity 66.7% (chlorin E6), 65.4% (5ALA). For grade IV glioma surgery, the sensitivity of the method is 87.5% (chlorin E6), 87.7% (5ALA); specificity-85.7% (chlorin E6), 85.3% (5ALA). CONCLUSION: Statistical analysis showed comparable high efficacy of the drugs in the surgery of malignant gliomas. The sensitivity and specificity of the method for fluorescent preparations of chlorin E6 and 5 ALA showed no statistically significant difference in the achievement of the result (p> 0.05).