Mixed micelle formation between amphiphilic drug amitriptyline hydrochloride and surfactants (Conventional and Gemini) at 293.15-308.15 K

Abstract

The micellization of amphiphilic drug amitriptyline hydrochloride (AMT, an antidepressant) and conventional as well as gemini surfactants has been studied conductometrically in pure and mixed states in aqueous solutions at different temperatures to derive various physicochemical properties such as critical micelle concentration (cmc), ideal cmc (cmcid), counterion dissociation (g), standard Gibbs free energy (δGm0), enthalpy (δHm0), and entropy of micellization (δSm0), micellar mole fractions of surfactant (X1, X1m), mole fraction of surfactant in ideal state (X1id), interaction parameter (β), activity coefficients (f1, f2), and excess free energy of mixing (δGex). All the results indicate synergism and attractive interactions in the mixed systems. © 2010 American Chemical Society.