Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes

Abstract

Background: PTP1B is a negative modulator of insulin receptor-mediated signaling. Results: Acetaminophen increased PTP1B in hepatocytes and impaired insulin signaling. Conclusion: PTP1B plays an essential role in the impairment of insulin signaling mediated by acetaminophen in hepatocytes. Significance: Chronic acetaminophen administration might be associated with insulin resistance in the liver.