Frontispiece: Hydrogen Bonding: Regulator for Nucleophilic Fluorination

Abstract

One of the most important interactions in Nature, that is, hydrogen bonding, can be utilized for regulating nucleophilic fluorination using two readily available nucleophilic fluorine sources: hydrogen fluoride and alkali metal fluorides. The former comprises HF/DMPU, in which the strong hydrogen bonding acceptor DMPU fine-tunes the nucleophilicity of HF. Within the latter category, the non-controllable nucleophilicity and strong basicity of alkali-metal fluorides can be fine-tuned through hydrogen bonding interactions using various strategies. For more details, see the Minireview by G. B. Hammond, B. Xu and S. Liang on page 17850 ff.