Two new pyrrolidine alkaloids, radicamines A and B, as inhibitors of α-glucosidase from Lobelia chinensis Lour

Abstract

Two new pyrrolidine alkaloids, radicamines A and B were isolated as inhibitors of α-glucosidase from Lobelia chinensis Lour. (Campanulaceae). Radicamines A and B were formulated as (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(3-hydroxy-4-methoxyphenyl)- pyrrolidine (1) and (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine (2) on the basis of spectroscopic analyses and chemical methods.