Effect of transit times on quantification of cerebral blood flow by the FAIR T1-difference approach

Abstract

The effect of finite transit times for the tagging bolus is known to be a significant error source for perfusion quantification using the flow- sensitive alternating inversion recovery (FAIR) technique. It is shown that, in the presence of transit times, both the slice-selective (SS) and nonselective (NS) inversion recovery experiments actually consist of an NS period followed by an SS period. This mixed process can be described using a newly defined time constant called the 'switching time,' which separates the two periods. Calculations predict that finite transit times always lead to decreased flow values in the signal-intensity-difference approach, but that the measured flows in the T1-difference approach may be decreased or increased. This theory well explains our recent experimental flow results on cat brain as a function of predelay. The results show the signal-intensity- difference method is superior over the T1-difference approach in terms of convenience and ease of quantification.