Antidiabetic Activity Assessment of Syzygium jambos Extract in Zebrafish Administered Alloxan

Abstract

Diabetes mellitus is a very common metabolic disturbance affecting the carbohydrate catabolic pathway. Not only carbohydrates but other macromolecules also fluctuate during this disease. Type 2 diabetes mellitus promptly originates because of the resistance of insulin functioning in the cells. The study assessed the anti-diabetic activity of the methanolic fruit extract of Syzygium jambos along with its wound-healing potential. Diabetes in the zebrafish was induced with 100-300 mg/kg of alloxan and various parameters were assessed, such as abnormality score assay, light and dark assay, acute and chronic toxicity, fasting and postprandial blood glucose level. After treatment of zebrafish with 1-7 mg/ml of methanolic fruit extract of S. jambos, most of the tested parameters were decreased. Also, wound healing was noted in the zebrafish in the form of fine regeneration after the administration of fruit extract (10µl/ml to 10mg/ml of extract).