Two new secondary metabolites from xylaria sp. cfcc 87468

Abstract

A new isocoumarin glycoside, 3R-(+)-5-O-[6'-O-Acetyl]-A-D-glucopyranosyl-5- hydroxymellein (1), and a new phenylethanol glycoside, (-)-phenylethyl-8-O-A-L- rhamnopyranoside (2), were isolated from the ethyl acetate extract of the fungus Xylaria sp. cfcc 87468, together with five known steroids, ß-sitosterol (3), stigmast-4-en-3- one (4), ergosterol (5), (22E)-cholesta-4,6,8(14),22- tetraen-3-one (6), and 4a-methylergosta- 8(14),24(28)-dien-3ß-ol (7). The structures of compounds 1 and 2 were elucidated by MS, extensive 1D and 2D NMR spectroscopy, and the circular dichroism (CD) spectroscopy.