Transition-metal free oxidative aliphatic C-H fluorination

Abstract

A practical and highly selective fluorination of unactivated aliphatic C-H bonds without the use of transition metals has been developed. This C-H fluorination protocol is robust, operationally simple, scalable and compatible with moisture and air. Furthermore, the method exhibits a broad substrate scope and is applicable to late-stage fluorination of natural products and derivatives, which make it a valuable method for the synthesis of fluorinated complex molecules.