Selective mono- and 1,4-di-N-alkylations of 1,4,7,10-tetraazacyclododecane

Abstract

General methods for selective N-alkylations of the macrocycle 1,4,7,10-tetraazacyclododecane have been developed. The N-monoalkylation proceeds via a cyclic guanidinium derivative, and the rcgioseleclive 1,4-N,N-dialkylation via a cyclic amidinium derivative. All transformations were high yield reactions. © Acta Chemica Scandinavica 1998.