Convenient indole synthesis from 2-iodoanilines and terminal alkynes by the sequential sonogashira reaction and the cyclization reaction promoted by tetrabutylammonium fluoride (TBAF)

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Abstract

The sequential Sonogashira reaction and the cyclization reaction of various 2-iodoanilines and terminal alkynes in the presence of a palladium catalyst and tetrabutylammonium fluoride (TBAF) gave the corresponding 2-substituted indoles in good yields. © 2003 Pharmaceutical Society of Japan.

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Suzuki, N., Yasaki, S., Yasuhara, A., & Sakamoto, T. (2003). Convenient indole synthesis from 2-iodoanilines and terminal alkynes by the sequential sonogashira reaction and the cyclization reaction promoted by tetrabutylammonium fluoride (TBAF). Chemical and Pharmaceutical Bulletin, 51(10), 1170–1173. https://doi.org/10.1248/cpb.51.1170

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