Synthesis of steroidal dimers: Selective amine catalysed steroidal dimerization

Abstract

Some new dimeric steroids namely cholest-5-en-3-spiro-[6′ α,5′-oxa]-5′ α-cholest-3′-one (2) , cholest-5-en-7-spiro-[4′ α,5′-oxa]-5′ α-cholest-7′-one (4a) and 3β-substitutedcholest-5-en-7-spiro- [4′ α,5′-oxa]- 3′ β-substituted-5′ α-cholestan-7′-ones (4b, c) are synthesized starting from cholest-5-en-3-one (1) , cholest-5- en-7-one (3a) and 3β-substituted- cholest-5-en-7-ones (3b, c) respectively by using DMAP and xylene. All the synthesized compounds were characterized by using IR, MS and 1H, 13C NMR spectral and elemental analysis. © Indian Academy of Sciences.