Β-Arrestin promotes wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of amer1 protein

Abstract

Background: Β-Arrestins are required for Wnt/Β-catenin signaling, but the mechanism of their action is unclear. Results: Β-Arrestins bind PtdInsP2-interacting protein Amer1, bind PtdInsP2-producing kinases, and control Wnt3a-induced PtdInsP2 production and Amer1 membrane dynamics. Conclusion:Β-Arrestins bridge Wnt3a-induced Dvl-associated PtdInsP2 production to the phosphorylation of Lrp6 via control of Amer1 dynamics. Significance: The first mechanistic explanation how Β-arrestin regulates Wnt/Β-catenin signaling is provided. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.