Synthesis and comparative study on the antibacterial activity organotin(IV) 3-hydroxybenzoate compounds

Abstract

The synthesis and comparative study on the antibacterial activity of three organotin(IV) compounds, namely dibutyltin(IV) bis-(3-hydroxybenzoate), [Bu2Sn(3-HBz)2] (7), diphenyltin(IV) bis-(3-hydroxybenzoate), [Ph2Sn(3-HBz)2] (8), and triphenyltin(IV) 3-hydroxybenzoate, [Ph3Sn(3-HBz)] (9) which were prepared by the reaction of dibutyltin(IV) oxide, [Bu2SnO] (4), diphenyltin(IV) dihydroxide, [Ph2Sn(OH)2] (5), and triphenyltin(IV) hydroxide, [Ph3SnOH] (6) with 3-hydroxybenzoic acid (3-HBz) has successfully been performed. The characterization of these compounds were done using 1H and 13C NMR, IR, UV spectroscopies and their compositions were determined based on microanalytical data. Antibacterial activity of these compounds was demonstrated at concentrations of 1.89 × 10-4, 1.81 × 10-4, and 1.72 × 10-4 M, respectively by dilution method against Pseudomonas aeruginosa. Similarly, the compounds were active at concentration of 1.87 × 10-4, 1.79 × 10-4, and 1.71 × 10-4 M, respectively, against Bacillus subtilis. These activities are comparable to that of streptomycin at a concentration of 1.70 × 10-4 M as a positive control, but the halozone of compounds 7, 8, and 9 were slightly lower than that of streptomycin's halozone. The results obtained suggest that the compounds synthesized have potential as antibacterial agents.