Progressive multifocal cerebral infarction in a young kidney transplant recipient due to thrombotic microangiopathy

Abstract

Background: Renal transplant recipients frequently experience neurological complications. Whereas ischemic stroke, cerebral haemorrhage or hypertensive encephalopathy often result from vascular alterations prior to transplantation, other cerebral diseases like CNS infections, primary brain tumors and drug induced neurotoxicity may develop as consequences of the required post-transplant immunosuppressive treatment. Case presentation. Here we report on an unusual clinical course of a young kidney transplant recipient with a cluster of fulminant necrotic brain lesions within a period of two months due to thrombotic microangiopathy. Conclusion: Cerebral ischemia in organ transplant recipients should prompt one to consider thrombotic microangiopathy. © 2014 Haghikia et al.; licensee BioMed Central Ltd.