Antidiabetic, antioxidant and anti-inflammatory activity of medicinal plants collected from nearby area of Junagadh, Gujarat

Abstract

Phytochem. and to evaluate in vitro antidiabetic, antioxidant and anti-inflammatory activities of different extracts of six medicinal plants collected from nearby area of Junagadh, Gujarat, India, viz., L. echinata (fruit), O. turpethum Silva Manso (leaf), S. indicus L. (fruit), C. cretica L. (leaf), C. depressus L. (root) and C. absus (seed). In vitro antidiabetic activity was evaluated by alpha-amylase and alpha-glucosidase inhibition methods, antioxidant activity by DPPH assay and anti-inflammatory activity by albumin denaturation assay. Hydro-alc. and methanolic extracts of L. echinata, water extract of C. cretica and methanolic and hydro-alc. extracts of C. depressus showed significant inhibition either of alpha-amylase or alpha-glucosidase in vitro at various concentrations Hydro-alc. and methanolic extracts of L. echinata fruit and hydroalcoholic and methanolic extracts of S. indicus fruit showed significant in vitro antioxidant effect. Water extract of O. turpethum leaf showed significant anti-inflammatory activity by preventing albumin denaturation in vitro. Phytochem. anal. revealed presence of glycosides, flavonoids, alkaloids, tannins and steroids in different extracts of medicinal plants which might be responsible for significant in vitro antidiabetic, antioxidant and anti-inflammatory activities. Identification and isolation of active substances from such plants and in vivo efficacy evaluation will be helpful for further validation of pharmacol. activities of these medicinal plants.