Single-Molecule Identification of Nucleotides Using a Quantum Computer

Abstract

Genomic information is essential for human health. Due to its large volume, genomic information can be potentially computed using quantum computers, which are rapidly developing. Genome analysis using quantum computers can accelerate the development of personalized medicine, innovative drugs, and novel diagnostics based on genomic information. However, genomic analysis, including nucleotide identification, has not yet been performed using quantum computers. Here, we demonstrate single-molecule identification of nucleotides using a quantum computer. We have designed a quantum gate that explains the single-molecule conductance of adenosine electronically bonded between electrodes. The quantum circuit consists of a reverse and an encoding quantum gate that can strongly distinguish adenosine among the four nucleotides. Our results are the first step toward the realization of genome analysis using quantum computers.