Microbiota associated with peri-implantitis—A systematic review with meta-analyses

Abstract

Aim: To answer the following PECO question: “In systemically healthy human subjects (P), which are the differences between peri-implantitis (E) and peri-implant health/mucositis (C) in terms of bacterial presence/count (O)?”. Materials and Methods: Cross-sectional studies fulfilling specific inclusion criteria established to answer the PECO question were included. Two review authors independently searched for studies, screened the titles and abstracts, did full-text analysis, extracted the data from the included reports, and performed the risk of bias assessment through an adaptation of the Newcastle/Ottawa tool for cross-sectional studies and of the JBI critical appraisal checklist. In case of disagreement, a third reviewer author took the final decision. Study results were summarized using random effects meta-analyses. Results: A total of 12 studies were included, involving 1233 participants and 1513 implants. Peri-implantitis was associated with the presence of S. epidermidis (Odds ratio, OR = 10.28 [95% Confidence interval, CI: 1.26–83.98]), F. nucleatum (OR = 7.83 [95% CI: 2.24–27.36]), T. denticola (OR = 6.11 [95% CI: 2.72–13.76]), T. forsythia (OR = 4.25 [95% CI: 1.71–10.57]), P. intermedia (OR = 3.79 [95% CI: 1.07–13.35]), and P. gingivalis (OR = 2.46 [95% CI: 1.21–5.00]). Conversely, the presence of A. actinomycetemcomitans (OR = 3.82 [95% CI: 0.59–24.68]), S. aureus (OR = 1.05 [95% CI: 0.06–17.08]), and C. rectus (OR = 1.48 [95% CI: 0.69–3.17]) was not associated with peri-implantitis. Conclusions: Peri-implantitis is associated with the presence of S. epidermidis and specific periodontopathogens (P. gingivalis, T. forsythia, T. denticola, F. nucleatum, and P. intermedia). (CRD42021254589).