Effect of embolisation of meningioma on Ki-67 proliferation index

Abstract

The proliferation indices (PIs) wer determined in 33 meningiomas using tw monoclonal antibodies to the Ki-67 anti gen (Ki-67 and MIBM). PIs obtaine using Ki-67 on frozen material wer intermediate between the lowest an highest MIBI PIs determined in paraffli wax sections. Preoperative embolisatioi did not influence Ki67 PI, but four of thi 15 embolised tumours showed substan tially increased MIBI PIs aroun embolisation necroses. Proliferation can be reliably assesse in routinely processed meningioma tis sues using MIBI; and increased per inecrotic PIs may occur in embolise meningiomas without being an indica tion of malignancy.