The effect of induced liver, kidney and lung lesions on the toxicity of levamisole and diazinon in calves

Abstract

Liver damage in calves, produced by the oral administration of the flukecide, carbon tetrachloride, increased the toxic effect of diazinon but not of levamisole, whereas the presence of a renal tubular lesion caused by mercuric chloride enhanced the toxicity of both commonly used anthelmintic compounds. The toxicity of diazinon was increased in calves with a lung lesion caused by oral dosing with tryptophan, an agent implicated in 'fog fever' of cattle. © 1987.