Effects of continuous exposure to bisphenol a on male and female mice from prenatally to adulthood

Abstract

BisphenolA (BPA), a monomer estrogenic chemical of many plastic products has controversial biological effects. This study assessed the effects at 0.05 mg/kg BW/day (Tolerable Daily Intake, TDI) and 0.5 mg/kg BW/day (10TDI), in male and female mice continuously exposed from embryo to adulthood. Results found BPA at the expected safe dose (TDI) decreased anogenital distance index (AGDI), motile sperm count, and ejaculation frequency, increased cauda epididymis weight and ejaculation latency in male mice, increased lordosis quotient in female mice. 10TDI decreased motile sperm counts, decreased intromission latency, unable to perform ejaculation in male mice, shortened AGDI in female mice. Other systems, at TDI, male mice had increased aggressive scores. At 10TDI, both male and female mice had increased body weights at 4 weeks and aggressive scores at 8-9 weeks. Mated female mice had increased internal organ weights at 13 weeks after pup delivery. The adverse effects on reproductive and related systems were confirmed.