Allelic Polymorphism of Endothelial No-Synthase (eNOS) Association with Exercise-Induced Hypoxia Adaptation

Abstract

study the influence of polymorphisms of this gene on individual values of resistance to hypoxia, a gas analysis was conducted in the athletes practicing rowing. During the study the eNOS gene expression was examined in athletes practicing short-course underwater finswimming with apneapracticing long distance swimming with a snorkel. Results: The findings are evidence of a possible variant of influence of polymorphism of the eNOS gene on the phenotype formation resistant to exercise-induced hypoxia. Conclusions: In the athletes practicing underwater finswimming, the occurrence of the allelic variant of С/С Т-786→С promoter polymorphism and Т/Т-variant in exon 7 of the gene of NO-synthase is lower than in the general population of Ukraine and in the athletes of speed and power type of sports, which may be the result of selection and be important for peculiarities of the development of resistance to exercise-induced hypoxia with different types of muscle activity.