DoriC: A database of oriC regions in bacterial genomes

Abstract

Replication origins (oriC s) of bacterial genomes currently available in GenBank have been predicted by using a systematic method comprising the Z-curve analysis for nucleotide distribution asymmetry, DnaA box distribution, genes adjacent to candidate oriC s and phylogenetic relationships. These oriC s are organized into a MySQL database, DoriC, which provides extensive information and graphical views of the oriC regions. In addition, users can Blast a query sequence or even a whole genome against DoriC to find a homologous one. DoriC will be updated timely and the latest version is DoriC 1.8, in which oriC s of 425 genomes (468 chromosomes) are identified. © The Author 2007. Published by Oxford University Press. All rights reserved.