Osmolalidade plasmática e osmol gap em eqüinos desidratados experimentalmente

Abstract

Ten equines were experimentally dehydrated. Plasma osmolality calculated (POC), plasma osmolality measured (POM) and osmol gap were evaluated. The dehydration was induced by furosemide 1mg/kg bodyweight, intravenous injection (three applications at 7 a.m., 3 p.m. and 11 p.m.) in the first 24 hours associated to 72 hours of food and water fasting. Blood was sampled at 0, 12, 24, 36, 48, 60 and 72 hours of experiment. Plasma osmolality was evaluated by two ways: osmometry (POM) and the evaluation of sodium, potassium, glucose and urea concentrations in blood (POC). The osmol gap was calculated subtracting the values of POC from POM. According to the results, the equines presented mild hypertonic dehydration. POC was not efficient to estimate POM in dehydrated equines. Osmol gap was useful to determinate the presence of unmeasured osmotically active substances in blood.