Synthesis and Characterization of 1,3,5-Trisubstituted Pyrazoline Derivatives by Ultrasonic Irradiation Method and Evaluation of its Antibacterial Activity

Abstract

A series of novel 1,3,5-trisubstituted pyrazoline derivatives (P 1 -P 10 ) have been synthesized by the reaction of substituted chalcones (C 1 -C 10 ) with 4-hydroxybenzhydrazide. The starting material, chalcones were prepared by claisen Schmidt condensation of 4-methylacetophenone with substituted aldehydes in the presence of sodium hydroxide in ethanol. 4-hydroxybenzhydrazide was synthesized by condensing methyl 4-hydroxybenzoate with hydrazine hydrate. The cycloaddition of chalcones with 4-hydroxybenzhydrazide gives 1, 3, 5-trisubstituted pyrazoline derivatives. The structures of synthesized derivatives were confirmed by IR, 1 HNMR and 13 C NMR spectrum. The synthesized compounds were screened for their antibacterial and antifungal activity.