Temporal cortex dopamine D2/3 receptor binding in major depression

Abstract

The aim of this study was to assess the dopamine function of the temporal cortex in major depressive disorder using [123I]epidepride to image D2/3 receptor binding sites. Ten major depressives and 10 healthy controls were selected from a general population sample for single-photon emission computed tomography imaging. Among the major depressives there was a strong bilateral correlation between the scores on the 21-item Hamilton Depression Rating Scale and D2/3 receptor binding. Dopaminergic abnormalities may be present in the temporal cortices of major depressives. © 2008 The Authors.