Synthesis and single crystal x-ray structure of bis[4-oxo-3-(2- ethoxycarbonylphenyl)-3,4-dihydroquinazolin-2-yl]disulfide

Abstract

Diethyl 2,2'-thiocarbonyl-bis(azanediyl)dibenzoate was synthesized from the reaction of ethyl anthranilate with thiophosgene. Its treatment with sodium ethoxide in ethanol at room temperature gave ethyl 2-(4-oxo-2-thioxo-1,2- dihydroquinazolin-3(4H)-yl) benzoate, whereas in the presence of ethyl nitroacetate and under the same reaction conditions, the corresponding bis(quinazolin)disulfide was formed. Its structure was confirmed by IR, 1Hand 13C NMR spectroscopy elemental analysis and single crystal X-ray structure determination. © 2009 Verlag der Zeitschrift für Naturforschung, Tün.