Comparative Study of Serum Lipid Profile in Preeclampsia and Normal Pregnancy

Abstract

Background: Preeclampsia affects 5-15% of pregnancies and is a major cause of maternal, fetal and neonatal morbidity and mortality worldwide. The aim of the study was to demonstrate a positive correlation between dyslipidemia and preeclampsia. Method & Materials: This study was a case control study conducted in the Post Graduate Department of Obstetrics and Gynecology, Government Lal Ded Hospital Srinagar. A total of 200 (two hundred) were selected, out of which 100 (one hundred) normotensive pregnant women served as a control and 100 (one hundred) preeclampsia women constituted the study group. Besides baseline routine investigations, estimation of Serum lipid profile was done by collecting blood samples from antecubital vein of every case and control following a fast of 12-14 hours and collected in plain vials and were analysed at department of Biochemistry, Government Medical College Srinagar. Results: The preeclampsia group had a significant rise in Triglyceride (TG) and VLDL-C levels and decreased HDL-C levels as compared to the control group. Non-significant differences were observed for total cholesterol and LDL-C levels among case and controls. Conclusion: Abnormal lipid profile results during pregnant women plays an important role in development of pre-eclampsia.